A Modular Three-Component Approach for Site-selective Tandem Arene Thiophosphorylation.

Thiophosphates serve as pivotal reagents within the realms of both organic and inorganic synthesis, with their most notable applications observed in agricultural chemistry. This manuscript delineates a modular three-component synthetic strategy for site-selective arene C-H thiophosphorylation with thianthrenium salt, 1,4-diazabicyclo[2.2.2]octane-sulfur dioxide (DABSO), and diarylphosphine oxides as substrates. This approach facilitates the metal-free and green synthesis of a diverse spectrum of S-aryl phosphorothioates through C-H functionalization and late-stage modification showcasing practicality and broad applicability.