Acta oto-laryngologica. Supplementum · 2009
Taste disturbance after stapes surgery--clinical and experimental study.
СтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
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Ошибки и ограничения
История · было → стало
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Miuchi Shinya, Sakagami Masafumi, Tsuzuki Kenzo, Noguchi Koichi, Mishiro Yasuo, Katsura Hirokazu
Аннотация
CONCLUSION: Most of the clinical cases experienced taste disturbance after stapes surgery, and in a few cases this disturbance persisted for a long time. The animal experiment suggested the role of geniculate ganglion (GG) cells in nerve generation.
OBJECTIVES: To clinically examine taste disorder and its recovery after stapes surgery and experimentally demonstrate a role of GG.
PATIENTS AND METHODS: Taste function after preservation of chorda tympani nerve (CTN) in stapes surgery was prospectively investigated with a questionnaire and electrogustometry (EGM). Further, expression of neurotrophic factors in GG after injury of CTN was examined by in situ hybridization histochemistry (ISSH) and RT-PCR.
RESULTS: Among the cases, 15/18 (83.3%) were associated with taste disturbance and 6/18 (33.3%) were associated with tongue numbness 2 weeks after surgery; however, the symptoms ceased in 14/18 cases (77.8%). Two weeks after surgery, the EGM threshold was found to be elevated in 15/18 cases (83.3%), while in 10/18 cases (55.6%), it did not decrease until 1 year after surgery. Expression of ISSH and amplified bands of BDNF and GFR increased at 7 and 14 days after nerve injury in ipsilateral GGs and also increased at 7 days on the contralateral side.
OBJECTIVES: To clinically examine taste disorder and its recovery after stapes surgery and experimentally demonstrate a role of GG.
PATIENTS AND METHODS: Taste function after preservation of chorda tympani nerve (CTN) in stapes surgery was prospectively investigated with a questionnaire and electrogustometry (EGM). Further, expression of neurotrophic factors in GG after injury of CTN was examined by in situ hybridization histochemistry (ISSH) and RT-PCR.
RESULTS: Among the cases, 15/18 (83.3%) were associated with taste disturbance and 6/18 (33.3%) were associated with tongue numbness 2 weeks after surgery; however, the symptoms ceased in 14/18 cases (77.8%). Two weeks after surgery, the EGM threshold was found to be elevated in 15/18 cases (83.3%), while in 10/18 cases (55.6%), it did not decrease until 1 year after surgery. Expression of ISSH and amplified bands of BDNF and GFR increased at 7 and 14 days after nerve injury in ipsilateral GGs and also increased at 7 days on the contralateral side.
Предметные рубрики MeSH
AdultAnimalsBrain-Derived Neurotrophic FactorChorda Tympani NerveFemaleGeniculate GanglionGlial Cell Line-Derived Neurotrophic Factor ReceptorsHumansHypesthesiaIn Situ HybridizationMaleMiddle AgedOtosclerosisPostoperative ComplicationsProspective StudiesRNA, MessengerRatsRats, Sprague-DawleyStapes SurgerySurveys and QuestionnairesTaste DisordersTaste ThresholdTongue