Evaluation of Betatrophin, Chemerin, and Kisspeptin Levels in Acromegaly Patients.

BACKGROUND

Acromegaly is a chronic disorder characterized by excessive growth hormone (GH) secretion from pituitary somatotroph cells, resulting in metabolic complications and increased morbidity. Elevated levels of GH and insulin-like growth factor 1 (IGF-1) contribute to various metabolic and morphological abnormalities. Betatrophin, produced in the liver and adipose tissue, plays a significant role in regulating glucose and lipid metabolism. Chemerin, an adipokine, influences insulin sensitivity, lipid metabolism, and inflammation. Additionally, kisspeptin, a neuropeptide, stimulates the secretion of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) through the hypothalamic-pituitary-gonadal axis.

OBJECTIVE

This study aimed to investigate the levels of betatrophin, chemerin, and kisspeptin in acromegaly patients and their potential relationship with dyslipidemia and diabetes.

METHODS

This study included 40 patients diagnosed with acromegaly and 40 healthy controls. GH and IGF-1 levels were measured, and venous blood samples were analyzed for betatrophin, chemerin, and kisspeptin levels using ELISA.

RESULTS

The analysis revealed no significant difference in betatrophin levels between acromegaly patients and controls (p>0.05). However, significantly lower levels of chemerin and kisspeptin were observed in patients with acromegaly (p<0.001). Furthermore, a significant correlation was identified between IGF-1 and kisspeptin levels, indicating a potential pathway for future research in diagnostics and therapy.

CONCLUSION

This study highlights the altered levels of chemerin and kisspeptin in acromegaly patients, suggesting their involvement in metabolic dysregulation associated with the condition. Further investigation into the correlation between IGF-1 and kisspeptin could provide insights into developing targeted therapeutic strategies.