Future medicinal chemistry · 2024
Exploring biological activities of novel Schiff bases derived from amlodipine and in silico molecular modeling studies.
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Masood Anum, Khan Mohsin Abbas, Bhat Mashooq A, Awan Breena, Hanif Ramsha, Raza Asim, Khaliq Saharish, Ahmed Javaid, Ullah Farhat
Аннотация
Aim: Calcium channel antagonists are of considerable interest in treating elevated blood pressure and its pathologies.Materials & methods: Schiff base derivatives of amlodipine were produced to check its urease inhibition potentials as well antibacterial and antioxidant activities. Structural illustration along with chemical characterization were achieved by spectral techniques (1H NMR, FTIR, 13C NMR) and docking studies also performed.Results & conclusion: 3g displayed remarkable anti-hypertensive activity compared with parent drug. 3b, 3f and 3g showed urease inhibition potentials. These compounds can aid as lead for further investigations since they exhibited comparable or superior interactions.