Simultaneous electrochemical recognition of tryptophan and penicillamine enantiomers based on MOF-modified β-CD.

Chiral recognition is of significant importance in the fields of chemical asymmetric synthesis and biological pharmaceutical research. In this work, an electrochemical chiral sensor with two kinds of chiral sites (chiral cavity for β-cyclodextrin and chiral skeleton for Ca-sacc/MeOH) by electrooxidation β-cyclodextrin onto Ca-sacc/MeOH was built. The proposed multichiral β-CD@Ca-sacc/MeOH/GCE can be used for recognition of tryptophan and penicillamine enantiomers simultaneously with wide linear range, low detection limits value, high repeatability and stability within the available electrochemical window. The strategy for integration multichiral sources is crucial to construct novel chiral platforms for simultaneous recognition of multiple chiral compounds in complicated chiral systems.