Frontiers in dental medicine · 2026
Clinical and radiographic outcomes of Aloe vera as a pulpotomy medicament in primary teeth: a systematic review.
СтатьяСистематический обзорНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
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Uchil Samiksha, R Manju, Bhandary Meghna, B Sadhvi, Shetty Urvashi
Аннотация
INTRODUCTION: Pulpotomy is a common vital pulp therapy in primary molars aimed at preserving radicular pulp vitality until exfoliation. Concerns regarding the cytotoxicity and systemic effects of formocresol have prompted interest in biocompatible alternatives such as Aloe vera, which possesses anti-inflammatory, antimicrobial, and regenerative properties.
AIM: To evaluate the clinical and radiographic success of Aloe vera as a pulpotomy medicament in primary molars compared to conventional agents.
METHODS: A systematic search of PubMed, Scopus and Web of Science was conducted in accordance with PRISMA guidelines. Randomized controlled trials evaluating Aloe vera as a pulpotomy medicament in primary molars were included. Risk of bias was assessed using the Cochrane RoB2 tool, and the certainty of evidence for primary outcomes was evaluated using the GRADE approach.
RESULTS: Clinical success at 3-6 months was high (90%-100%) and comparable between groups. However, radiographic success was highly inconsistent; two major trials reported significantly lower success for Aloe vera (21.1% and 54.8%) compared to formocresol at 6-12 months.
CONCLUSION: Aloe vera demonstrates promising short-term clinical performance, but it showed less predictable radiographic outcomes and was inferior to standard comparators in some trials. Due to the Very Low certainty of evidence and high risk of bias in major studies, herbal agents cannot currently be recommended as definitive substitutes for formocresol or MTA.
SYSTEMATIC REVIEW REGISTRATION: https://www.crd.york.ac.uk/PROSPERO/view/CRD420251230179, PROSPERO, identifier CRD420251230179.
AIM: To evaluate the clinical and radiographic success of Aloe vera as a pulpotomy medicament in primary molars compared to conventional agents.
METHODS: A systematic search of PubMed, Scopus and Web of Science was conducted in accordance with PRISMA guidelines. Randomized controlled trials evaluating Aloe vera as a pulpotomy medicament in primary molars were included. Risk of bias was assessed using the Cochrane RoB2 tool, and the certainty of evidence for primary outcomes was evaluated using the GRADE approach.
RESULTS: Clinical success at 3-6 months was high (90%-100%) and comparable between groups. However, radiographic success was highly inconsistent; two major trials reported significantly lower success for Aloe vera (21.1% and 54.8%) compared to formocresol at 6-12 months.
CONCLUSION: Aloe vera demonstrates promising short-term clinical performance, but it showed less predictable radiographic outcomes and was inferior to standard comparators in some trials. Due to the Very Low certainty of evidence and high risk of bias in major studies, herbal agents cannot currently be recommended as definitive substitutes for formocresol or MTA.
SYSTEMATIC REVIEW REGISTRATION: https://www.crd.york.ac.uk/PROSPERO/view/CRD420251230179, PROSPERO, identifier CRD420251230179.