Abnormalities of resting-state EEG in patients with prodromal and overt dementia with Lewy bodies: Relation to clinical symptoms.
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Pascarelli Maria Teresa, Del Percio Claudio, De Pandis Maria Francesca, Ferri Raffaele, Lizio Roberta, Noce Giuseppe, Lopez Susanna, Rizzo Marco, Soricelli Andrea, Nobili Flavio, Arnaldi Dario, Famà Francesco, Orzi Francesco, Buttinelli Carla, Giubilei Franco, Salvetti Marco, Cipollini Virginia, Franciotti Raffaella, Onofri Marco, Fuhr Peter, Gschwandtner Ute, Ransmayr Gerhard, Aarsland Dag, Parnetti Lucilla, Farotti Lucia, Marizzoni Moira, D'Antonio Fabrizia, De Lena Carlo, Güntekin Bahar, Hanoğlu Lutfu, Yener Görsev, Emek-Savaş Derya Durusu, Triggiani Antonio Ivano, Paul Taylor John, McKeith Ian, Stocchi Fabrizio, Vacca Laura, Hampel Harald, Frisoni Giovanni B, Bonanni Laura, Babiloni Claudio
Аннотация
METHODS: We extracted clinical, demographic and rsEEG datasets in matched DLB patients (N = 60) and control Alzheimer's disease (AD, N = 60) and healthy elderly (Nold, N = 60) seniors from our international database. The eLORETA freeware was used to estimate cortical rsEEG sources.
RESULTS: As compared to the Nold group, the DLB and AD groups generally exhibited greater spatially distributed delta source activities (DLB > AD) and lower alpha source activities posteriorly (AD > DLB). As compared to the DLB "controls", the DLB patients with (1) rapid eye movement (REM) sleep behavior disorders showed lower central alpha source activities (p < 0.005); (2) greater cognitive deficits exhibited higher parietal and central theta source activities as well as higher central, parietal, and occipital alpha source activities (p < 0.01); (3) visual hallucinations pointed to greater parietal delta source activities (p < 0.005).
CONCLUSIONS: Relevant clinical features were associated with abnormalities in spatial and frequency features of rsEEG source activities in DLB patients.
SIGNIFICANCE: Those features may be used as neurophysiological surrogate endpoints of clinical symptoms in DLB patients in future cross-validation prospective studies.