Evaluation of the Antitumor Effect of High-Energy Protons, Helium Ions, and Carbon during Irradiation of Ehrlich Adenocarcinoma Ascites Cells Ex Vivo.

The regularities of tumor induction and growth in mice were studied during a single ex vivo irradiation of Ehrlich adenocarcinoma ascites cells with a beam of protons, helium ions (4Не), and carbon ions (12С) at doses of 10, 20, and 30 Gy. It was shown that, when tumor cells were exposed to all types of radiation, a dose-dependent increase in the antitumor effect was observed in the latent period of tumor appearance, the frequency of their induction, and tumor growth inhibition. According to all indices, 12C had the greatest antitumor effect, 4He occupied an intermediate position, and protons caused the least effect.