European journal of obstetrics, gynecology, and reproductive biology · 2012
Follicular fluid concentrations of IGF-I, IGF-II, IGFBP-3, VEGF, AMH, and inhibin-B in women undergoing controlled ovarian hyperstimulation using GnRH agonist or GnRH antagonist.
Сравнительное исследованиеСтатьяРандомизированное исследованиеНазвание и аннотация: Перевод в очереди
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Kaya Aysenur, Atabekoglu Cem S, Kahraman Korhan, Taskin Salih, Ozmen Batuhan, Berker Bulent, Sonmezer Murat
Аннотация
OBJECTIVE: To compare follicular fluid concentrations of IGF-I, IGF-II, IGFBP-3, inhibin-B, VEGF, and AMH in women undergoing controlled ovarian hyperstimulation with a long-luteal GnRH agonist protocol or multiple-dose GnRH antagonist protocol.
STUDY DESIGN: A total of 80 cycles were included; long-luteal GnRH agonist group (n=40) and multiple dose GnRH antagonist group (n=40). All follicular fluid samples were obtained from mature follicles during oocyte retrieval. IGF-I and IGFBP-3 concentrations were measured by immunoradiometric assay. IGF-II, VEGF, AMH, and inhibin-B concentrations were measured by enzyme-linked immunosorbent assay.
RESULTS: There were no significant differences in the concentrations of the studied follicular fluid markers, cycle parameters, and treatment outcomes between GnRH agonist and GnRH antagonist protocols.
CONCLUSIONS: The long-luteal GnRH agonist protocol and multiple-dose GnRH antagonist protocol seem to have similar effects on the follicular microenvironment in women undergoing controlled ovarian hyperstimulation.
STUDY DESIGN: A total of 80 cycles were included; long-luteal GnRH agonist group (n=40) and multiple dose GnRH antagonist group (n=40). All follicular fluid samples were obtained from mature follicles during oocyte retrieval. IGF-I and IGFBP-3 concentrations were measured by immunoradiometric assay. IGF-II, VEGF, AMH, and inhibin-B concentrations were measured by enzyme-linked immunosorbent assay.
RESULTS: There were no significant differences in the concentrations of the studied follicular fluid markers, cycle parameters, and treatment outcomes between GnRH agonist and GnRH antagonist protocols.
CONCLUSIONS: The long-luteal GnRH agonist protocol and multiple-dose GnRH antagonist protocol seem to have similar effects on the follicular microenvironment in women undergoing controlled ovarian hyperstimulation.
Предметные рубрики MeSH
AdultAnti-Mullerian HormoneBiomarkersFemaleFertility Agents, FemaleFollicular FluidGonadotropin-Releasing HormoneHumansInfertilityInfertility, FemaleInhibinsInsulin-Like Growth Factor Binding Protein 3Live BirthOvarian FollicleOvulation InductionPregnancyPregnancy RateSomatomedinsTherapeutic EquivalencyTurkeyVascular Endothelial Growth Factor AYoung Adult