An unusual presentation of early congenital syphilis with annular configuration of blisters resembling "string-of-pearls".

Skin lesions in early congenital syphilis can show considerable variability. A 35-day-old infant presented with rhinitis, desquamation of palms and soles, pseudoparalysis of the right upper limb, and annular lesions with peripheral blistering over the chest and abdomen, resembling a "string-of-pearls." A diagnosis of congenital syphilis was made on the basis of radiologic evaluation and reactive Venereal Disease Research Laboratory (VDRL) in both mother and child. We report this case to highlight the unusual presentation of congenital syphilis with annular configuration of blisters, mimicking a "string-of-pearls."