Effect of inhaled peppermint essential oil aromatherapy on postoperative nausea and vomiting in patients undergoing laparoscopic gynecologic surgery.

BACKGROUND

This study evaluated the effect of inhaled peppermint essential oil (PEO) aromatherapy on postoperative nausea and vomiting (PONV) in patients undergoing laparoscopic gynecologic surgery.

METHODS

In this randomized controlled trial, 106 patients were assigned to either the PEO group or normal saline (NS) group. The PEO group received inhalational aromatherapy with 2% peppermint oil before induction, preoperatively, and immediately after extubation. The NS group received an identical intervention using 2 ml of 0.9% sodium chloride solution.

RESULTS

Compared with the NS group, the PEO group had a significantly lower incidence of PONV within 24 h (52.8% vs. 73.6%; p = 0.043). The reduction was most notable during the first hour (45.3% vs. 73.6%; p = 0.047). The PEO group also demonstrated significantly improved anxiety scores at 0-24 h and 24-48 h, reduced pain catastrophizing, and decreased abdominal distension.

CONCLUSION

Inhaled peppermint aromatherapy reduced the incidence of PONV, improved anxiety, decreased pain catastrophizing, and alleviated abdominal distension in patients undergoing laparoscopic gynecological surgery.

CLINICAL TRIAL REGISTRATION: This study was registered in the Chinese Clinical Trial Registry. (Registration number: ChiCTR2400093289 Registration Date:2024-12-02).