Proliferative Necrotising Otitis Externa in a Cat Treated Successfully With Oclacitinib Maleate With Two Delayed Relapses.

This case report documents the successful treatment of a cat with proliferative necrotizing otitis externa (PNOE) using oclacitinib. Novel to this report, two episodes of delayed relapses occurred prior to complete spontaneous resolution, with an apparent dose-dependent response to oclacitinib. Oclacitinib led to complete remission of the initial lesions and those of the first relapse, and the lesions of the second relapse resolved spontaneously. This adds additional evidence to support the use of oclacitinib as an alternative or adjunctive off-label treatment for PNOE, especially in refractory cases. Further studies are needed to assess the safety of long-term use, and to confirm ideal dose rates and treatment duration.