Veterinary anaesthesia and analgesia · 2024
Sedative effects of intramuscular alfaxalone-methadone-midazolam versus ketamine-methadone-midazolam in cats.
СтатьяRandomized Controlled Trial, VeterinaryНазвание и аннотация: Перевод в очереди
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Te Poele Elles, de Vries Annemarie, de Grauw Janny
Аннотация
OBJECTIVE: To assess depth and quality of sedation and the ability to place an intravenous catheter in cats after intramuscular (IM) injection with alfaxalone-methadone-midazolam (AMM) or ketamine-methadone-midazolam (KMM).
STUDY DESIGN: Blinded randomized clinical trial.
ANIMALS: A group of 46 healthy Domestic Short Hair cats.
METHODS: Cats were randomly assigned to be administered IM methadone 0.3 mg kg-1 and midazolam 0.3 mg kg-1 with either alfaxalone 2 mg kg-1 (AMM group, n = 23) or ketamine 3 mg kg-1 (KMM group, n = 23). Before IM injection, a temperament score was assigned. The reaction to injection was scored. After 15 minutes, the depth of sedation was scored using a simple descriptive scale (SDS) and multidimensional sedation score. Success or failure to place an intravenous catheter at first attempt was recorded; p < 0.05.
RESULTS: Cats in the AMM group had a significantly higher median temperament score (p = 0.026). Behavioural reaction to injection with AMM was significantly less compared with KMM (p = 0.016). Median sedation scores were significantly higher in the AMM group than in the KMM group: SDS 4 (0-4) versus 2 (0-4), p = 0.01, respectively; multidimensional sedation score AMM 13 (0-13) versus 3 (0-10), indicating superior sedative effect in the AMM group, p = 0.01. Success rate of catheter placement was significantly higher in the AMM group (18/23) than in the KMM group (10/23), p = 0.033.
CONCLUSIONS: and clinical relevance Addition of 2 mg kg-1 alfaxalone to 0.3 mg kg-1 methadone and 0.3 mg kg-1 midazolam provided better sedation after IM injection than ketamine 3 mg kg-1 combined with the same doses of methadone and midazolam. This combination of drugs may be particularly desirable as an alternative to α-2 adrenoceptor agonist-based protocols for cats requiring IM sedation.
STUDY DESIGN: Blinded randomized clinical trial.
ANIMALS: A group of 46 healthy Domestic Short Hair cats.
METHODS: Cats were randomly assigned to be administered IM methadone 0.3 mg kg-1 and midazolam 0.3 mg kg-1 with either alfaxalone 2 mg kg-1 (AMM group, n = 23) or ketamine 3 mg kg-1 (KMM group, n = 23). Before IM injection, a temperament score was assigned. The reaction to injection was scored. After 15 minutes, the depth of sedation was scored using a simple descriptive scale (SDS) and multidimensional sedation score. Success or failure to place an intravenous catheter at first attempt was recorded; p < 0.05.
RESULTS: Cats in the AMM group had a significantly higher median temperament score (p = 0.026). Behavioural reaction to injection with AMM was significantly less compared with KMM (p = 0.016). Median sedation scores were significantly higher in the AMM group than in the KMM group: SDS 4 (0-4) versus 2 (0-4), p = 0.01, respectively; multidimensional sedation score AMM 13 (0-13) versus 3 (0-10), indicating superior sedative effect in the AMM group, p = 0.01. Success rate of catheter placement was significantly higher in the AMM group (18/23) than in the KMM group (10/23), p = 0.033.
CONCLUSIONS: and clinical relevance Addition of 2 mg kg-1 alfaxalone to 0.3 mg kg-1 methadone and 0.3 mg kg-1 midazolam provided better sedation after IM injection than ketamine 3 mg kg-1 combined with the same doses of methadone and midazolam. This combination of drugs may be particularly desirable as an alternative to α-2 adrenoceptor agonist-based protocols for cats requiring IM sedation.