Wei sheng yan jiu = Journal of hygiene research · 2010
[Subchronic toxicity test of genetically modified rice with double antisense starch-branching enzyme gene].
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Li Min, Piao Jianhua, Yang Xiaoguang
Аннотация
OBJECTIVE: To observe the sub-chronic toxic effects of the genetically modified rice with double antisense SBE gene.
METHODS: Based on gender and weight, weanling Wistar rats were randomly sorted into five groups: non-genetically modified rice group (group A), genetically modified rice group (group B), half genetically modified rice group (group C), quarter genetically modified rice group (group D) and AIN-93G normal diet group (group E). Indicators were the followings: body weight, food consumption, blood routine, blood biochemical test, organ weight, bone density and pathological examination of organs.
RESULTS: At the middle of the experiment, the percentage of monocyte of female group B was less than that of group E (P < 0.05). AST activity of female group B was higher than that of group E (P < 0.05). ALT activity of female group C was higher than that of groups A and E (P < 0.05). At the end of the experiment, AST and ALT activities of female group B were higher than those of group E (P < 0.05). Hematocrit (HCT) and blood urea nitrogen (BUN) level of male group B were less than those of group A (P < 0.05), and monocyte was higher than that of group E (P < 0.05). The brain index of female group B was higher than group A (P < 0.05) and the kidney index of group E were higher than those of groups B, C and D (P < 0.05). There were no significant difference of blood lipids, calcium and bone mineral density among all groups (P > 0.05), and no notable abnormity in the pathological examination of main organs (P > 0.05).
CONCLUSION: There were no enough evidence to confirm the sub-chronic toxicity of genetically modified rice on rats.
METHODS: Based on gender and weight, weanling Wistar rats were randomly sorted into five groups: non-genetically modified rice group (group A), genetically modified rice group (group B), half genetically modified rice group (group C), quarter genetically modified rice group (group D) and AIN-93G normal diet group (group E). Indicators were the followings: body weight, food consumption, blood routine, blood biochemical test, organ weight, bone density and pathological examination of organs.
RESULTS: At the middle of the experiment, the percentage of monocyte of female group B was less than that of group E (P < 0.05). AST activity of female group B was higher than that of group E (P < 0.05). ALT activity of female group C was higher than that of groups A and E (P < 0.05). At the end of the experiment, AST and ALT activities of female group B were higher than those of group E (P < 0.05). Hematocrit (HCT) and blood urea nitrogen (BUN) level of male group B were less than those of group A (P < 0.05), and monocyte was higher than that of group E (P < 0.05). The brain index of female group B was higher than group A (P < 0.05) and the kidney index of group E were higher than those of groups B, C and D (P < 0.05). There were no significant difference of blood lipids, calcium and bone mineral density among all groups (P > 0.05), and no notable abnormity in the pathological examination of main organs (P > 0.05).
CONCLUSION: There were no enough evidence to confirm the sub-chronic toxicity of genetically modified rice on rats.