American journal of human genetics · 2001
A genomewide search for quantitative-trait loci underlying asthma.
СтатьяПоддержка исследования: вне правительства СШАПоддержка службы здравоохранения СШАНазвание и аннотация: Перевод в очереди
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Xu X, Fang Z, Wang B, Chen C, Guang W, Jin Y, Yang J, Lewitzky S, Aelony A, Parker A, Meyer J, Weiss S T, Xu X
Аннотация
A genomewide screen for quantitative-trait loci (QTLs) that underlie asthma was performed on 533 Chinese families with asthma, by the unified Haseman-Elston method. Nine asthma-related phenotypes were studied, including forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC), airway responsiveness as indicated by methacholine (MTCH)-challenge test, serum total immunoglobulin E (TIgE), serum-specific immunoglobulin E, eosinophil count in peripheral blood, and skin-prick tests with three different allergens (cockroach, Dermatophagoides pteronyssinus, and D. farinae). Our study showed significant linkage between airway responsiveness to MTCH and D2S1780 on chromosome 2 (P<.00002) and provided suggestive evidence (P<.002) for six additional possible QTLs: D10S1435 and D22S685, for FEV1; D16S412, for FVC; D19S433, for airway responsiveness to MTCH; D1S518, for TIgE; and D4S1647, for skin reactivity to cockroach. No significant or suggestive evidence of linkage for the other four traits was found.
Предметные рубрики MeSH
AdultAllergensAnimalsAntigens, DermatophagoidesAsthmaBronchoconstrictor AgentsChinaChromosome MappingChromosomes, HumanChromosomes, Human, Pair 2CockroachesEosinophilsFemaleForced Expiratory VolumeGenetic LinkageGlycoproteinsHumansImmunoglobulin ELeukocyte CountMaleMethacholine ChloridePhenotypeQuantitative Trait, HeritableSkin TestsVital Capacity