Predictors of complicated course of acute myocardial infarction with ST-segment elevation in patients with obesity, overweight and normal body weight.

OBJECTIVE

Aim: The aim of the study was to clarify the influence of smoking and other risk factors (RFs) on the occurrence of complications in patients with normal body weight, overweight (OW) and obesity.

PATIENTS AND

METHODS

Materials and

Methods

Patients (n=158) with acute ST-segment elevation myocardial infarction (STEMI) were divided into 3 groups depending on body mass index (BMI): Group I included 52 patients with normal body weight (mean age - 60.83±11.94 years); Group II - 51 patients with OW (mean age - 62.04±8.55 years); Group III - 55 patients with obesity of I-III degree (mean age - (0.96±11.31 years) (p>0.05).

RESULTS

Results

The most common RFs were hypertension (88.46-94.55%), dyslipidemia (DLP) (50.00-76.36%), smoking (69.23-69.09%). The relative risk of acute left ventricular aneurysm in Group I with DLP is 2.08 times higher (RR=2.08 [0.37; 11.62], p=0.029), and among smokers, this risk increases by 25% (RR=1.25 [0.22; 7.18], p=0.049). The relative risk of major complications in Group II in the presence of 5-6 RFs is 1,5 times higher (RR=1.58 [0.61; 10.94], p=0.016). The relative risk of all complications in Group III in the presence of DLP is 1.23 times higher (RR=1.23, with 95% CI from 0.91 to 1.65, p=0.017), and in the presence of smoking is 8.37 times higher RR=8.37 [2.11; 33.16], p<0.001).

CONCLUSION

Conclusions

Complications are observed three times more often in obese patients and about twice as often in overweight patients. Significant predictors of complications are smoking, dyslipidemia, simultaneous exposure to 5-6 risk factors. Smoking increases the risk of complications by 8 times in obese patients.