Fertility and sterility · 2004
Assisted reproductive techniques in patients with Klinefelter syndrome: a critical review.
СтатьяСистематический обзорНазвание и аннотация: Перевод в очереди
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Denschlag Dominik, Tempfer Clemens, Kunze Myriam, Wolff Gerhard, Keck Christoph
Аннотация
OBJECTIVE: To summarize the existing experience with the use and success rate of assisted reproductive techniques (ART), in particular testicular sperm extraction (TESE) and intracytoplasmic sperm injection (ICSI), in Klinefelter patients.
DESIGN: A systematic review of the literature, including all published case reports to date.
PATIENT(S): Thirty-nine reported successful pregnancies fathered by nonmosaic Klinefelter patients.
MAIN OUTCOME MEASURE(S): The overall risk of transmitting a chromosomal abnormality to the offspring of Klinefelter patients.
RESULT(S): In nonmosaic and mosaic Klinefelter patients, chromosomally normal sperm cells can be extracted from testicular tissue and used for ICSI.
CONCLUSION(S): The application of ART to Klinefelter patients can be recommended as a method to achieve reproduction in this selected infertility patient cohort.
DESIGN: A systematic review of the literature, including all published case reports to date.
PATIENT(S): Thirty-nine reported successful pregnancies fathered by nonmosaic Klinefelter patients.
MAIN OUTCOME MEASURE(S): The overall risk of transmitting a chromosomal abnormality to the offspring of Klinefelter patients.
RESULT(S): In nonmosaic and mosaic Klinefelter patients, chromosomally normal sperm cells can be extracted from testicular tissue and used for ICSI.
CONCLUSION(S): The application of ART to Klinefelter patients can be recommended as a method to achieve reproduction in this selected infertility patient cohort.