Journal of infection in developing countries · 2026
Pleural effusion caused by Rickettsia felis infection.
СтатьяКлинический случайНазвание и аннотация: Перевод в очереди
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Ren Hong, Zhang Yingying, Zhang Xue, Zhang Hanwen, Chang Li, Gao Lingyun, Li Lin, Zhang Gaoyang
Аннотация
INTRODUCTION: Rickettsia felis, a Gram-negative obligate intracellular prokaryotic organism, causes human infections with atypical clinical presentations, commonly including fever, fatigue, headache, and maculopapular rash.
CASE PRESENTATION: This study presents a rare case of pleural effusion (PE) associated with R. felis infection, confirmed through targeted next-generation sequencing (tNGS). The patient showed significant clinical improvement and resolution of PE following empirical moxifloxacin followed by pathogen-directed therapy with rifampicin and azithromycin, along with supportive measures for circulation and immune function.
CONCLUSIONS: This case report aims to enhance early diagnosis and therapeutic strategies for R. felis infections by sharing the diagnostic and management experience.
CASE PRESENTATION: This study presents a rare case of pleural effusion (PE) associated with R. felis infection, confirmed through targeted next-generation sequencing (tNGS). The patient showed significant clinical improvement and resolution of PE following empirical moxifloxacin followed by pathogen-directed therapy with rifampicin and azithromycin, along with supportive measures for circulation and immune function.
CONCLUSIONS: This case report aims to enhance early diagnosis and therapeutic strategies for R. felis infections by sharing the diagnostic and management experience.