A Novel Approach to Aplasia Cutis Congenita With PolyNovo BTM.

Aplasia cutis congenita (ACC) is a rare congenital condition characterized by the absence of skin and subcutaneous tissue, typically affecting the scalp. This case report presents a female infant born at 38+3 weeks with a posterior midline scalp defect measuring 15×12.5 mm, involving skin, subcutaneous tissue, and calvarium. The defect was managed with NovoSorb Biodegradable Temporising Matrix (BTM). Initially, the plan involved a subsequent skin graft; however, the defect epithelized without grafting. By 2 months, the wound had healed completely, and by 6 months, the underlying bone had ossified. ACC presents with significant variability, and management strategies range from conservative treatment to surgical intervention depending on defect size. This case demonstrates the successful use of a fully synthetic dermal substitute in managing full-thickness scalp defects, providing a novel, effective option for treating ACC without requiring grafting.