Visible-Light-Induced C(sp3)-H Activation for Minisci Alkylation of Pyrimidines Using CHCl3 as Radical Source and Oxidant.

A highly efficient Minisci reaction of pyrimidines with alkyl radical generated from visible-light-induced activation of simple C(sp3)-H feedstocks such as (cyclo)alkanes, ethers, alcohols, esters, and amides is reported. A mechanistic study revealed that alkyl radical was generated via hydrogen atom transfer (HAT) of C(sp3)-H with dichloromethyl radical (·CHCl2), which was generated by photoreduction of chloroform.