Characteristics Associated With Breakthrough Congenital Syphilis in Florida and Arizona, 2018-2022.

Congenital syphilis (CS) can occur despite timely identification and adequate treatment of maternal syphilis (breakthrough CS). We examined associations between maternal characteristics and prevalence of breakthrough CS. Having primary/secondary syphilis, a higher maximum nontreponemal titer, and treatment initiation closer to delivery were associated with a higher prevalence of breakthrough CS.