Diagnosis of Primary Ciliary Dyskinesia. An Official American Thoracic Society Clinical Practice Guideline.
Обработка статьи · этапы, ошибки и управление
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Shapiro Adam J, Davis Stephanie D, Polineni Deepika, Manion Michele, Rosenfeld Margaret, Dell Sharon D, Chilvers Mark A, Ferkol Thomas W, Zariwala Maimoona A, Sagel Scott D, Josephson Maureen, Morgan Lucy, Yilmaz Ozge, Olivier Kenneth N, Milla Carlos, Pittman Jessica E, Daniels M Leigh Anne, Jones Marcus Herbert, Janahi Ibrahim A, Ware Stephanie M, Daniel Sam J, Cooper Matthew L, Nogee Lawrence M, Anton Billy, Eastvold Tori, Ehrne Lynn, Guadagno Elena, Knowles Michael R, Leigh Margaret W, Lavergne Valery, American Thoracic Society Assembly on Pediatrics
Аннотация
TARGET AUDIENCE: Clinicians investigating adult and pediatric patients for possible PCD.
METHODS: Systematic reviews and, when appropriate, meta-analyses were conducted to summarize all available evidence pertinent to our clinical questions. Evidence was assessed using the GRADE (Grading of Recommendations, Assessment, Development and Evaluation) approach for diagnosis and discussed by a multidisciplinary panel with expertise in PCD. Predetermined conflict-of-interest management strategies were applied, and recommendations were formulated, written, and graded exclusively by the nonconflicted panelists. Three conflicted individuals were also prohibited from writing, editing, or providing feedback on the relevant sections of the manuscript.
RESULTS: After considering diagnostic test accuracy, confidence in the estimates for each diagnostic test, relative importance of test results studied, desirable and undesirable direct consequences of each diagnostic test, downstream consequences of each diagnostic test result, patient values and preferences, costs, feasibility, acceptability, and implications for health equity, the panel made recommendations for or against the use of specific diagnostic tests as compared with using the current reference standard (transmission electron microscopy and/or genetic testing) for the diagnosis of PCD.
CONCLUSIONS: The panel formulated and provided a rationale for the direction as well as for the strength of each recommendation to establish the diagnosis of PCD.