F&S reports · 2026
Relationship between endometriosis diagnosis, staging, and typology and inflammatory cytokines.
СтатьяНазвание и аннотация: Перевод в очереди
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Shaaban May, Ryan Jeanna T, Adediran Emmanual, Farland Leslie V, Pollack Anna Z, Peterson C Matthew, Rexrode Kathryn M, Hemmert Rachael, Paulsen Madeline, Brown Benjamin H, Spiess Saskia T, Varner Michael W, Schliep Karen C
Аннотация
OBJECTIVE: To study whether incident endometriosis diagnosis, staging, and typology are associated with concurrent elevated serum inflammatory markers interleukin-6 (IL-6), interleukin-8 (IL-8), and tumor necrosis factor alpha (TNF- α ).
DESIGN: Cross-sectional analysis using data from the Endometriosis, Natural History, Diagnosis, and Outcomes (ENDO) study.
SUBJECTS: A total of 395 premenopausal females in Utah, with no prior endometriosis diagnosis, participating in diagnostic or therapeutic gynecologic laparoscopy/laparotomy, 2007-2009.
EXPOSURE: Endometriosis diagnosis, staging (minimal, mild, moderate, severe), and typology (superficial endometriosis [SE], deep infiltrating endometriosis [DE], ovarian endometrioma [OE]), determined through postoperative reports and the revised American Society for Reproductive Medicine classification.
MAIN OUTCOME MEASURE: Elevated serum cytokine concentrations defined as IL-6 ≥2 pg/mL, IL-8 ≥3 pg/mL, and TNF-α ≥7.5 pg/mL. Adjusted prevalence ratios (aPR) and 95% confidence intervals (CI) were estimated using generalized linear models controlling for age, body mass index (BMI), race/ethnicity, serum cotinine, and reported use of oral hormonal contraception within the past 2 years.
RESULTS: Participants were on average 33 years at time of gynecologic laparoscopy/laparotomy, non-Hispanic white (79%), married (75%), with a BMI of 18.5-24.9 kg/m2 (39%), nonsmokers (83% serum cotinine <5 ng/mL), and reported use of oral hormonal contraception within the past 2 years (23%). Forty-two percent (n = 166) were diagnosed with incident endometriosis. Ten percent had elevated IL-6, 7% had elevated IL-8, and 13% had elevated TNF- α , with 26% having an elevation of at least one marker. We found no differences between those with, vs. without, endometriosis and prevalence of elevated serum IL-6 (10% vs. 10%; aPR: 1.17; 95% CI: 0.59, 2.30), IL-8 (5% vs. 8%; aPR: 0.60; 95% CI: 0.20, 1.84), or TNF- α (16% vs. 12%; aPR: 1.30; 95% CI: 0.68, 2.51). There was also no indication that endometriosis was associated with continuous measures of IL-6, IL-8, or TNF- α or that staging or typology was associated with any of the inflammatory biomarkers.
CONCLUSION: This study found no associations between incident endometriosis diagnosis, staging, typology, and concurrent serum inflammatory markers IL-6, IL-8, and TNF- α . Our results are in line with several other studies finding null associations between systemic cytokines, measured via blood-derived specimens, and endometriosis. Whether other cardiovascular disease risk biomarkers, including lipoprotein abnormalities, are associated with endometriosis warrants further research.
DESIGN: Cross-sectional analysis using data from the Endometriosis, Natural History, Diagnosis, and Outcomes (ENDO) study.
SUBJECTS: A total of 395 premenopausal females in Utah, with no prior endometriosis diagnosis, participating in diagnostic or therapeutic gynecologic laparoscopy/laparotomy, 2007-2009.
EXPOSURE: Endometriosis diagnosis, staging (minimal, mild, moderate, severe), and typology (superficial endometriosis [SE], deep infiltrating endometriosis [DE], ovarian endometrioma [OE]), determined through postoperative reports and the revised American Society for Reproductive Medicine classification.
MAIN OUTCOME MEASURE: Elevated serum cytokine concentrations defined as IL-6 ≥2 pg/mL, IL-8 ≥3 pg/mL, and TNF-α ≥7.5 pg/mL. Adjusted prevalence ratios (aPR) and 95% confidence intervals (CI) were estimated using generalized linear models controlling for age, body mass index (BMI), race/ethnicity, serum cotinine, and reported use of oral hormonal contraception within the past 2 years.
RESULTS: Participants were on average 33 years at time of gynecologic laparoscopy/laparotomy, non-Hispanic white (79%), married (75%), with a BMI of 18.5-24.9 kg/m2 (39%), nonsmokers (83% serum cotinine <5 ng/mL), and reported use of oral hormonal contraception within the past 2 years (23%). Forty-two percent (n = 166) were diagnosed with incident endometriosis. Ten percent had elevated IL-6, 7% had elevated IL-8, and 13% had elevated TNF- α , with 26% having an elevation of at least one marker. We found no differences between those with, vs. without, endometriosis and prevalence of elevated serum IL-6 (10% vs. 10%; aPR: 1.17; 95% CI: 0.59, 2.30), IL-8 (5% vs. 8%; aPR: 0.60; 95% CI: 0.20, 1.84), or TNF- α (16% vs. 12%; aPR: 1.30; 95% CI: 0.68, 2.51). There was also no indication that endometriosis was associated with continuous measures of IL-6, IL-8, or TNF- α or that staging or typology was associated with any of the inflammatory biomarkers.
CONCLUSION: This study found no associations between incident endometriosis diagnosis, staging, typology, and concurrent serum inflammatory markers IL-6, IL-8, and TNF- α . Our results are in line with several other studies finding null associations between systemic cytokines, measured via blood-derived specimens, and endometriosis. Whether other cardiovascular disease risk biomarkers, including lipoprotein abnormalities, are associated with endometriosis warrants further research.