Ceska gynekologie · 2008
[Survival in children with birth defects during first year of their life].
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Gregor V, Sípek A, Horácek J, Sípek A, Langhammer P
Аннотация
OBJECTIVE: To analyze infant mortality in children with selected types of birth defects during a first year of their life.
DESIGN: A retrospective study with an analysis of prenatal and postnatal occurrence of birth defects in the Czech Republic during 1994 - 2006.
SETTING: Department of Medical Genetics, Thomayer's University Hospital, Prague. Chair of Medical Genetics, Postgraduate Medical Institute, Prague.
METHODS: Data were collected from national registers (Institute of Health Information and Statistics) and particular departments of medical genetics. A study of frequency of 14 selected birth defects was performed along with an analysis of survival and mortality in children with birth defects during a first year of their life.
RESULTS: In 1994 - 2006, totally 1 132 567 children were born in the Czech Republic, out of which more than 42 000 with a birth defect. A mean incidence was 339 per 10 000 live births with a maximum of 41458 per 10 000 in 2003. In correctible defects, first year survival was lowest in congenital hydrocephalus (72%) and neural tube defects (anencephaly excluded) (71%). In congenital defects of gastro-intestinal tract and in abdominal wall defects survival was between 82-91%.
CONCLUSION: Birth defects present an important contribution to an infant mortality and morbidity in the first year of life. In a comparison of 1980 - 1993 and 1994 - 2006 periods, a significant increase of prenatal diagnostics efficiency was recorded.
DESIGN: A retrospective study with an analysis of prenatal and postnatal occurrence of birth defects in the Czech Republic during 1994 - 2006.
SETTING: Department of Medical Genetics, Thomayer's University Hospital, Prague. Chair of Medical Genetics, Postgraduate Medical Institute, Prague.
METHODS: Data were collected from national registers (Institute of Health Information and Statistics) and particular departments of medical genetics. A study of frequency of 14 selected birth defects was performed along with an analysis of survival and mortality in children with birth defects during a first year of their life.
RESULTS: In 1994 - 2006, totally 1 132 567 children were born in the Czech Republic, out of which more than 42 000 with a birth defect. A mean incidence was 339 per 10 000 live births with a maximum of 41458 per 10 000 in 2003. In correctible defects, first year survival was lowest in congenital hydrocephalus (72%) and neural tube defects (anencephaly excluded) (71%). In congenital defects of gastro-intestinal tract and in abdominal wall defects survival was between 82-91%.
CONCLUSION: Birth defects present an important contribution to an infant mortality and morbidity in the first year of life. In a comparison of 1980 - 1993 and 1994 - 2006 periods, a significant increase of prenatal diagnostics efficiency was recorded.