Prediction Criteria for the Formation of Refracture after Union of a Long Bone Fracture on the Basis of Hemodynamic Changes in the Tissues of the Area of Damage.

We studied hemodynamic changes in the area of leg bone fracture and determined the prognostic criteria for refracture formation after achieved union. In Wistar rats (n=18), shin bone fracture with external fixation of the fragments was modeled. The union was formed 35 days after osteosynthesis, the device was removed at this term. In 5 cases, a refracture was formed after the termination of fixation. Hemodynamics and local temperature in the tissues in the area of injury were recorded before the start of the experiment and on days 21 and 35 of fixation. In rats with refracture after union, the blood circulation in the area of damage was characterized by a pronounced hypertonicity of the arteries of both large and small diameters, obstruction of venous outflow, and local hyperthermia. This hemodynamics in tissues in the area of damage can serve as an informative criterion for predicting the course of reparative osteogenesis.