Journal of acquired immune deficiency syndromes (1999) · 2011
The interrelated transmission of HIV-1 and cytomegalovirus during gestation and delivery in the offspring of HIV-infected mothers.
СтатьяПоддержка NIH: внешняя программаПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Khamduang Woottichai, Jourdain Gonzague, Sirirungsi Wasna, Layangool Prapaisri, Kanjanavanit Suparat, Krittigamas Pornsuda, Pagdi Karin, Somsamai Rosalin, Sirinontakan Surat, Hinjiranandana Temsiri, Ardonk Wanna, Hongsiriwon Suchat, Nanta Sirisak, Borkird Thitiporn, Lallemant Marc, McIntosh Kenneth, Ngo-Giang-Huong Nicole, Program for HIV Prevention and Treatment (PHPT) Study Group
Аннотация
Our objective was to analyze, in formula-fed infants, correlates of HIV mother-to-child transmission, including cytomegalovirus (CMV) infection. HIV-infected infants were matched with HIV uninfected by maternal HIV RNA in a case-control design. Infant CMV infection was determined by CMV IgG at 18 months and timed by earlier CMV IgM or CMV DNA. Correlations were assessed using logistic regression. In utero HIV infection was independently associated with congenital CMV infection (P = 0.01), intrapartum HIV infection with congenital-plus-intrapartum/neonatal CMV infection (P = 0.01), and overall HIV with overall CMV infection (P = 0.001), and prematurity (P = 0.004). Congenital and acquired CMV infections are strong independent correlates of mother-to-child HIV transmission.
Предметные рубрики MeSH
AdultAnti-HIV AgentsCD4 Lymphocyte CountCytomegalovirusCytomegalovirus InfectionsFemaleHIV InfectionsHIV-1HumansInfantInfant, Low Birth WeightInfant, NewbornInfectious Disease Transmission, VerticalLogistic ModelsPregnancyPregnancy Complications, InfectiousPremature BirthRetrospective StudiesViral LoadYoung AdultZidovudine