Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology · 2025
Effect of Lidocaine on Quinine-Induced Tinnitus in Guinea Pigs: A Focus on the Auditory Cortex.
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Kenmochi Mutsumi, Ochi Kentaro, Kinoshita Hirotsugu, Kasugai Shigeru, Nakamura Manabu, Komori Manabu
Аннотация
HYPOTHESIS: This study investigated whether intravenous lidocaine reverses auditory cortex changes induced by systemic quinine administration.
BACKGROUND: Quinine, like salicylate, is known to induce tinnitus. Previous studies have shown that salicylate-induced changes in the auditory cortex can be reversed by lidocaine, a compound known to suppress tinnitus. If lidocaine also reverses quinine-induced changes, it would further support the association between these neural changes and the presence of tinnitus.
METHODS: Healthy male albino Hartley guinea pigs received systemic quinine, followed by intravenous lidocaine. Extracellular recordings were obtained from the primary auditory cortex and dorsocaudal areas across four sessions: baseline (control), two post-quinine sessions, and a post-lidocaine session.
RESULTS: A total of 156 single units in the primary auditory cortex and 159 single units in the dorsocaudal areas were recorded from 10 guinea pigs. Quinine administration significantly elevated threshold in both primary auditory cortex (first post-quinine session: mean, 3.2 dB; second post-quinine session: mean, 16.2 dB) and dorsocaudal areas (first post-quinine session: mean, 3.9 dB; second post-quinine session: mean, 11.0 dB), but lidocaine did not induce further threshold changes. However, quinine-induced alterations in Q10dB value and spontaneous firing activity were reversed by lidocaine in both the primary auditory cortex and dorsocaudal areas.
CONCLUSION: The reversal of quinine-induced changes in Q10dB value and spontaneous firing activity by lidocaine suggests that these neural alterations are related to tinnitus. Similar results with salicylate further support the association between cortical changes and tinnitus, pointing to a possible shared central mechanism.
BACKGROUND: Quinine, like salicylate, is known to induce tinnitus. Previous studies have shown that salicylate-induced changes in the auditory cortex can be reversed by lidocaine, a compound known to suppress tinnitus. If lidocaine also reverses quinine-induced changes, it would further support the association between these neural changes and the presence of tinnitus.
METHODS: Healthy male albino Hartley guinea pigs received systemic quinine, followed by intravenous lidocaine. Extracellular recordings were obtained from the primary auditory cortex and dorsocaudal areas across four sessions: baseline (control), two post-quinine sessions, and a post-lidocaine session.
RESULTS: A total of 156 single units in the primary auditory cortex and 159 single units in the dorsocaudal areas were recorded from 10 guinea pigs. Quinine administration significantly elevated threshold in both primary auditory cortex (first post-quinine session: mean, 3.2 dB; second post-quinine session: mean, 16.2 dB) and dorsocaudal areas (first post-quinine session: mean, 3.9 dB; second post-quinine session: mean, 11.0 dB), but lidocaine did not induce further threshold changes. However, quinine-induced alterations in Q10dB value and spontaneous firing activity were reversed by lidocaine in both the primary auditory cortex and dorsocaudal areas.
CONCLUSION: The reversal of quinine-induced changes in Q10dB value and spontaneous firing activity by lidocaine suggests that these neural alterations are related to tinnitus. Similar results with salicylate further support the association between cortical changes and tinnitus, pointing to a possible shared central mechanism.