Immunoglobulin deficiency and recurrent postmenopausal endometritis.

Secretory immunoglobulin A is the principal immunoglobulin of mucosal surfaces and may be reduced in postmenopausal women because of estrogen deficiency. This can manifest as recurrent infections and may be a cause of undiagnosed postmenopausal bleeding. Regular serum immunoglobulin therapy is appropriate for these patients.