Fertility and sterility · 2012
Ovarian response to controlled ovarian hyperstimulation in cancer patients is diminished even before oncological treatment.
СтатьяМногоцентровое исследованиеПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Domingo Javier, Guillén Vicente, Ayllón Yanira, Martínez María, Muñoz Elkin, Pellicer Antonio, Garcia-Velasco Juan A
Аннотация
OBJECTIVE: To evaluate the results of controlled ovarian stimulation before chemotherapy for oocyte vitrification to preserve fertility in women diagnosed with cancer and compare them with a historical control group.
DESIGN: A retrospective, multicenter, observational study performed between March 2007 and January 2011.
SETTING: University-affiliated infertility clinics.
PATIENT(S): Of 272 patients affected by cancer in our Fertility Preservation Program, 223 women underwent a stimulated cycle for oocyte vitrification according to our protocols before cancer treatment. Their results were compared with a historical control group of 98 patients diagnosed with male factor infertility who were stimulated for a conventional IVF cycle.
INTERVENTION(S): Controlled ovarian stimulation and oocyte retrieval.
MAIN OUTCOME MEASURE(S): Days of stimulation, total dose of gonadotropins, estrogen levels, and number of oocytes retrieved and vitrified.
RESULT(S): No differences were found in days of stimulation, but significant differences in E(2) levels and the number of retrieved oocytes were measured, especially in the hormone-dependent cancer group.
CONCLUSION(S): Patients with hormone-dependent cancer had a weaker response to controlled ovarian stimulation compared with patients with non-hormone-dependent cancer. Whether the oncological disease already affects the ovaries before chemo-/radiotherapy remains to be elucidated.
DESIGN: A retrospective, multicenter, observational study performed between March 2007 and January 2011.
SETTING: University-affiliated infertility clinics.
PATIENT(S): Of 272 patients affected by cancer in our Fertility Preservation Program, 223 women underwent a stimulated cycle for oocyte vitrification according to our protocols before cancer treatment. Their results were compared with a historical control group of 98 patients diagnosed with male factor infertility who were stimulated for a conventional IVF cycle.
INTERVENTION(S): Controlled ovarian stimulation and oocyte retrieval.
MAIN OUTCOME MEASURE(S): Days of stimulation, total dose of gonadotropins, estrogen levels, and number of oocytes retrieved and vitrified.
RESULT(S): No differences were found in days of stimulation, but significant differences in E(2) levels and the number of retrieved oocytes were measured, especially in the hormone-dependent cancer group.
CONCLUSION(S): Patients with hormone-dependent cancer had a weaker response to controlled ovarian stimulation compared with patients with non-hormone-dependent cancer. Whether the oncological disease already affects the ovaries before chemo-/radiotherapy remains to be elucidated.