Clinical and experimental obstetrics & gynecology · 2009
A case report supporting the concept that some women have a predisposition for maternal meiosis errors resulting in digyny.
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Check J H, Katsoff B, Summers-Chase D, Breitbart J
Аннотация
PURPOSE: To determine if a primary aborter with recurrent miscarriage times three with her only two fetal products that were evaluated with chromosome analysis demonstrating triploidy in both fetuses could have a predisposition for maternal meiosis errors.
METHODS: In vitro fertilization with intracytoplasmic sperm injection was performed. Embryo biopsy was performed on 3-day old embryos and a single blastomere was evaluated by fluorescent in situ hybridization (FISH). Embryo transfer would be performed on day 5 at the blastocyst stage.
RESULTS: There were six normal and seven abnormal embryos. One of the seven was a tetraploid embryo (92XXXX).
CONCLUSIONS: The majority of triploidies are related to polyspermy but this factor was excluded by performing ICSI. Thus this woman showed a marked predisposition to digyny. Though the tetraploidy could be explained by fertilization of a digynic egg by a diploid sperm the probability was that in this instance the meiosis error extended back to failure to extrude the first polar body.
METHODS: In vitro fertilization with intracytoplasmic sperm injection was performed. Embryo biopsy was performed on 3-day old embryos and a single blastomere was evaluated by fluorescent in situ hybridization (FISH). Embryo transfer would be performed on day 5 at the blastocyst stage.
RESULTS: There were six normal and seven abnormal embryos. One of the seven was a tetraploid embryo (92XXXX).
CONCLUSIONS: The majority of triploidies are related to polyspermy but this factor was excluded by performing ICSI. Thus this woman showed a marked predisposition to digyny. Though the tetraploidy could be explained by fertilization of a digynic egg by a diploid sperm the probability was that in this instance the meiosis error extended back to failure to extrude the first polar body.