Turkish neurosurgery · 2025
Using Patient-Reported Outcome Measures for Adult Chiari Malformation Type 1.
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Lima Guilherme, Souza-Filho Marlon Cesar, Oliveira-Junior Luiz, Paiva Daniel, Brock Roger Schmidt, Figueiredo Eberval Gadelha
Аннотация
AIM: To validate the Chicago Chiari Outcome Scale (CCOS) as a patient-reported outcome measures (PROMs) tool and identify the cutoffs of CCOS-PROM and EuroQoL-5D-3L score index (EQ-SI) against Gestalt in adults who underwent chiari malformation type 1 (CM1) treatment.
MATERIAL AND METHODS: This cross-sectional study analyzed the health status of CM1 adults after a 12-month surgery follow-up. An electronic form was sent to groups of CM patients. The self-Gestalt good perception was distributed as a cure or improvement for validation purposes. AUROC was evaluated to verify the ability of each PROM to predict Gestalt outcomes. Ethical approval registry: 64148822.0.0000.5292.
RESULTS: The 85 subjects had a mean age of 42.1(±10.6) years and a follow-up of 4.8(±4.1) years. Gestalt outcome was good for 23(27%) patients. The median CCOS-PROM of 74 patients was 11(IQR 4). The median EQ-SI of 84 patients was 0.52(IQR 0.29). CCOS-PROM score of 13 was the optimal cutoff value (sensitivity 82.6%; specificity 78.4%). For EQ-SI, this value was 0.64 (sensitivity 82.6%; specificity 75.4%). The AUROC for CCOS-PROM and EQ-SI were 0.90 and 0.86, respectively.
CONCLUSION: CCOS-PROM is valid for assessing the outcome of CM1 surgery in adults. CCOS-PROM score of 13 and EQ-SI of 0.64 were the best tradeoff values.
MATERIAL AND METHODS: This cross-sectional study analyzed the health status of CM1 adults after a 12-month surgery follow-up. An electronic form was sent to groups of CM patients. The self-Gestalt good perception was distributed as a cure or improvement for validation purposes. AUROC was evaluated to verify the ability of each PROM to predict Gestalt outcomes. Ethical approval registry: 64148822.0.0000.5292.
RESULTS: The 85 subjects had a mean age of 42.1(±10.6) years and a follow-up of 4.8(±4.1) years. Gestalt outcome was good for 23(27%) patients. The median CCOS-PROM of 74 patients was 11(IQR 4). The median EQ-SI of 84 patients was 0.52(IQR 0.29). CCOS-PROM score of 13 was the optimal cutoff value (sensitivity 82.6%; specificity 78.4%). For EQ-SI, this value was 0.64 (sensitivity 82.6%; specificity 75.4%). The AUROC for CCOS-PROM and EQ-SI were 0.90 and 0.86, respectively.
CONCLUSION: CCOS-PROM is valid for assessing the outcome of CM1 surgery in adults. CCOS-PROM score of 13 and EQ-SI of 0.64 were the best tradeoff values.