Cell reports · 2022
CD4 T cells are rapidly depleted from tuberculosis granulomas following acute SIV co-infection.
СтатьяПоддержка исследования: вне правительства СШАResearch Support, N.I.H., IntramuralНазвание и аннотация: Перевод в очереди
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Foreman Taylor W, Nelson Christine E, Kauffman Keith D, Lora Nickiana E, Vinhaes Caian L, Dorosky Danielle E, Sakai Shunsuke, Gomez Felipe, Fleegle Joel D, Parham Melanie, Perera Shehan R, Lindestam Arlehamn Cecilia S, Sette Alessandro, Tuberculosis Imaging Program, Brenchley Jason M, Queiroz Artur T L, Andrade Bruno B, Kabat Juraj, Via Laura E, Barber Daniel L
Аннотация
HIV/Mycobacterium tuberculosis (Mtb) co-infected individuals have an increased risk of tuberculosis prior to loss of peripheral CD4 T cells, raising the possibility that HIV co-infection leads to CD4 T cell depletion in lung tissue before it is evident in blood. Here, we use rhesus macaques to study the early effects of simian immunodeficiency virus (SIV) co-infection on pulmonary granulomas. Two weeks after SIV inoculation of Mtb-infected macaques, Mtb-specific CD4 T cells are dramatically depleted from granulomas, before CD4 T cell loss in blood, airways, and lymph nodes, or increases in bacterial loads or radiographic evidence of disease. Spatially, CD4 T cells are preferentially depleted from the granuloma core and cuff relative to B cell-rich regions. Moreover, live imaging of granuloma explants show that intralesional CD4 T cell motility is reduced after SIV co-infection. Thus, granuloma CD4 T cells may be decimated before many co-infected individuals experience the first symptoms of acute HIV infection.