Asian journal of transfusion science · 2024
Higher prevalence of anti-S and anti-M in South India: A single-center cross-sectional analytical study.
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Sriraman P, Sahoo Dibyajyoti, Basavarajegowda Abhishekh, Toora Esha
Аннотация
INTRODUCTION: Alloimmunization, a dreadful complication of blood transfusion, varies between populations and geographical regions. The antibody prevalence of the South Indian population was studied as the data were scarce. Rh-Kell matching is traditionally followed, but other alloantibodies may have higher prevalence because of geographical variation.
MATERIALS AND METHODS: It is a retrospective study on alloantibody prevalence in a tertiary care hospital in southern India from April 2021 to March 2023. The frequency, prevalence, and proportion of them are studied.
RESULTS: Out of 6640 patients, 1128 (16.98%) were Rh D negative. One hundred and thirty-three patients have 155 alloantibodies, among which anti-D is the most common (1.02%), followed by anti-C (0.21%) and S (0.19%), with none having anti-Kell alloantibodies. Here, 1.58% of alloantibodies are formed against Rh and Kell blood group system, whereas 1.94% are against Rh MNS and system.
CONCLUSION: Anti-M and anti-S are common alloantibodies prevalent in the southern India population besides Rh. The focus should be given to Rh-MNS-matched blood in our population.
MATERIALS AND METHODS: It is a retrospective study on alloantibody prevalence in a tertiary care hospital in southern India from April 2021 to March 2023. The frequency, prevalence, and proportion of them are studied.
RESULTS: Out of 6640 patients, 1128 (16.98%) were Rh D negative. One hundred and thirty-three patients have 155 alloantibodies, among which anti-D is the most common (1.02%), followed by anti-C (0.21%) and S (0.19%), with none having anti-Kell alloantibodies. Here, 1.58% of alloantibodies are formed against Rh and Kell blood group system, whereas 1.94% are against Rh MNS and system.
CONCLUSION: Anti-M and anti-S are common alloantibodies prevalent in the southern India population besides Rh. The focus should be given to Rh-MNS-matched blood in our population.