International journal of molecular sciences · 2026
High-Intensity Interval Training Snacks Improve Experimental Autoimmune Encephalomyelitis.
СтатьяНазвание и аннотация: Перевод в очереди
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Junior Oswaldo C, Viana Jully C S, Teixeira Lorranna E A, Filho Luiz G V, Corrêa Maria E H, Andrade Mariana F, Sperandio Ana C F, Caetano Giovanna P, Brito Philipe L, Salvador Maiara R, Pinheiro Liliane S, Dias-Peixoto Marco Fabrício, Carli Alessandra P, Alves Caio César de Souza, Castro Sandra B R
Аннотация
Several studies have shown that physical activity is associated with increased life expectancy and the prevention of chronic and neurodegenerative diseases. This study aimed to evaluate the impact of high-intensity interval training (HIIT) on the progression of an experimental model of multiple sclerosis. For this purpose, the murine model of experimental encephalomyelitis (EAE) was used in female C57BL/6 mice, divided into four groups: negative control (CN), positive control (EAE), HIIT once a day (1-HIIT), and HIIT snacks, three times a day (3-HIIT). The clinical score results demonstrated a significant reduction in the clinical score in mice subjected to 3-HIIT, confirmed by analyses of pro- and anti-inflammatory cytokines and histological analyses. These results provided solid evidence for the potential of HIIT protocols, especially 3-HIIT, to reprogram an autoimmune response in the CNS in mice with the EAE model, favoring a neuroprotective and immunoregulatory environment-evidence that may drive clinical research.