Expert review of clinical immunology · 2025
The clinical management of adult patients with Familial Mediterranean fever.
СтатьяОбзорНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Ruscitti Piero, Caso Francesco, Vitale Antonio, Giacomelli Roberto, Cantarini Luca
Аннотация
INTRODUCTION: Familial Mediterranean Fever (FMF) is the most common monogenic autoinflammatory disease worldwide. In this work, we reviewed the clinical management of FMF in adults also considering the possible development of additional issues in the long-term.
AREAS COVERED: A typical feature of FMF is the childhood onset, however, adult patients have been increasingly documented. The suspicion of adult onset FMF should be formulated when assessing a clinical picture characterized by systemic inflammatory episodes, apparently unprovoked, excluding other causes according to the diagnostic procedures for fever of unknown origin. The suspected clinical picture for autoinflammatory disease should not fulfill the criteria for diverse inflammatory diseases. Usually, the patients do not benefit following the administration of conventional immunosuppressants. Adult patients with FMF may experience some specific issues of the long-term disease, such as liver involvement and kidney failure, to be regularly monitored. Fertility concerns may also emerge with adulthood in patients with FMF, which should be carefully managed.
EXPERT OPINION: The possibility of occurrence of FMF is not completely excluded in adult patients, despite it could be characterized by atypical or delayed-onset presentations. Thus, raising the awareness toward the disease is of critical importance in improving the outcome of these patients.
AREAS COVERED: A typical feature of FMF is the childhood onset, however, adult patients have been increasingly documented. The suspicion of adult onset FMF should be formulated when assessing a clinical picture characterized by systemic inflammatory episodes, apparently unprovoked, excluding other causes according to the diagnostic procedures for fever of unknown origin. The suspected clinical picture for autoinflammatory disease should not fulfill the criteria for diverse inflammatory diseases. Usually, the patients do not benefit following the administration of conventional immunosuppressants. Adult patients with FMF may experience some specific issues of the long-term disease, such as liver involvement and kidney failure, to be regularly monitored. Fertility concerns may also emerge with adulthood in patients with FMF, which should be carefully managed.
EXPERT OPINION: The possibility of occurrence of FMF is not completely excluded in adult patients, despite it could be characterized by atypical or delayed-onset presentations. Thus, raising the awareness toward the disease is of critical importance in improving the outcome of these patients.