Infant behavior & development · 2010
Depressive symptoms during pregnancy: impact on neuroendocrine and neonatal outcomes.
СтатьяПоддержка NIH: внешняя программаПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Marcus Sheila, Lopez Juan F, McDonough Susan, Mackenzie Michael J, Flynn Heather, Neal Charles R, Gahagan Sheila, Volling Brenda, Kaciroti Niko, Vazquez Delia M
Аннотация
OBJECTIVE: To explore the interplay of maternal depressive symptoms on the infant limbic-hypothalamic-pituitary axis (LHPA) and neurological development.
DESIGN: Pregnant women were monitored for depressive symptoms using the Beck Depression Inventory (BDI) at 28, 32, and 37 weeks of gestation and at delivery. A mixture growth curve analysis divided the women into three risk groups: low/stable, intermediate, and high/increasing depression based on BDI scores. The infant neuroendocrine system was examined using cord blood for adrenocorticotrophic hormone (ACTH) and cortisol measurements. Two-week-old infants were examined using Neonatal Intensive Care Unit Neurobehavioral Scale (NNNS).
RESULTS: Infants born to women of the high/increasing depression group had significant ACTH elevation at birth. On NNNS examination, these infants were more hypotonic and habituated to auditory and visual stimuli.
CONCLUSION: When compared to non-depressed women, maternal depressive symptoms, even in the absence of major depressive disorder, appeared to facilitate a different developmental pathway for the infant LHPA and early neurological development.
DESIGN: Pregnant women were monitored for depressive symptoms using the Beck Depression Inventory (BDI) at 28, 32, and 37 weeks of gestation and at delivery. A mixture growth curve analysis divided the women into three risk groups: low/stable, intermediate, and high/increasing depression based on BDI scores. The infant neuroendocrine system was examined using cord blood for adrenocorticotrophic hormone (ACTH) and cortisol measurements. Two-week-old infants were examined using Neonatal Intensive Care Unit Neurobehavioral Scale (NNNS).
RESULTS: Infants born to women of the high/increasing depression group had significant ACTH elevation at birth. On NNNS examination, these infants were more hypotonic and habituated to auditory and visual stimuli.
CONCLUSION: When compared to non-depressed women, maternal depressive symptoms, even in the absence of major depressive disorder, appeared to facilitate a different developmental pathway for the infant LHPA and early neurological development.
Предметные рубрики MeSH
Adrenocorticotropic HormoneAdultDepressive DisorderEducational StatusEthnicityFemaleFetal BloodFetusHumansHydrocortisoneHypothalamo-Hypophyseal SystemIncomeInfant BehaviorInfant, NewbornIntensive Care Units, NeonatalLimbic SystemLongitudinal StudiesMaleMarital StatusNeurosecretory SystemsPregnancyPregnancy ComplicationsPregnancy OutcomeSocioeconomic FactorsYoung Adult