Emerging infectious diseases · 2015
Clinical course and long-term outcome of hantavirus-associated nephropathia epidemica, Germany.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Latus Joerg, Schwab Matthias, Tacconelli Evelina, Pieper Friedrich-Michael, Wegener Daniel, Dippon Juergen, Müller Simon, Zakim David, Segerer Stephan, Kitterer Daniel, Priwitzer Martin, Mezger Barbara, Walter-Frank Birgit, Corea Angela, Wiedenmann Albrecht, Brockmann Stefan, Pöhlmann Christoph, Alscher M Dominik, Braun Niko
Аннотация
Human infection with Puumala virus (PUUV), the most common hantavirus in Central Europe, causes nephropathia epidemica (NE), a disease characterized by acute kidney injury and thrombocytopenia. To determine the clinical phenotype of hantavirus-infected patients and their long-term outcome and humoral immunity to PUUV, we conducted a cross-sectional prospective survey of 456 patients in Germany with clinically and serologically confirmed hantavirus-associated NE during 2001-2012. Prominent clinical findings during acute NE were fever and back/limb pain, and 88% of the patients had acute kidney injury. At follow-up (7-35 mo), all patients had detectable hantavirus-specific IgG; 8.5% had persistent IgM; 25% had hematuria; 23% had hypertension (new diagnosis for 67%); and 7% had proteinuria. NE-associated hypertension and proteinuria do not appear to have long-term consequences, but NE-associated hematuria may. All patients in this study had hantavirus-specific IgG up to years after the infection.