Diabetes, obesity & metabolism · 2026
Associations of PM2 .5 and Its Constituents With the Dynamic and Accelerated Progression of Cardiovascular-Kidney-Metabolic Syndrome: The Gold-Health Cohort.
СтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Liu Hui, Wang Menghe, Lin Weiquan, Rao Manting, Zhuang Zitong, Yi Qian, Wei Shengtao, Zhang Chaoling, Chen Jiamin, Zhang Zhoubin, Chen Ge
Аннотация
BACKGROUND: The effects of exposure to fine particulate matter (PM2.5) constituents on the dynamic progression of cardiovascular-kidney-metabolic (CKM) syndrome remain unclear.
METHODS: Based on the Guangzhou Older Longitudinal Dynamic Health (GOLD-Health) cohort, we included 41 175 individuals at CKM stage 0-1, 266 016 at stage 2, and 206 692 at stage 3, classified according to American Heart Association guidelines. Individual-level exposures to PM2.5 and its five constituents-black carbon (BC), organic matter (OM), sulphate (SO4 2-), nitrate (NO3 -) and ammonium (NH4 +)-were estimated at geocoded residential addresses using bilinear interpolation. Multi-state models and accelerated failure time (AFT) models were applied to evaluate associations with dynamic CKM progression.
RESULTS: During 1.49 million person-years of follow-up, we documented 26 089 transitions from stage 0-1 to stage 2, 125 456 to stage 3, 18 561 to stage 4, and 39 614 deaths. Exposure to PM2.5 and all five constituents was significantly associated with CKM stage transitions, with effect estimates varying across stages. The transition from stage 3 to stage 4 showed the greatest risk, with a highest hazard ratio of 1.562 (95% CI: 1.548-1.577). AFT models further indicated that higher exposure levels were associated with accelerated CKM progression, with OM exhibiting the strongest effects across most transitions; for example, each standard deviation increase in OM exposure was associated with a 22.1% acceleration in transition time from stage 2 to stage 3.
CONCLUSION: Targeted mitigation of PM2.5 constituents, particularly organic matter, may help slow CKM progression and reduce the associated disease burden.
METHODS: Based on the Guangzhou Older Longitudinal Dynamic Health (GOLD-Health) cohort, we included 41 175 individuals at CKM stage 0-1, 266 016 at stage 2, and 206 692 at stage 3, classified according to American Heart Association guidelines. Individual-level exposures to PM2.5 and its five constituents-black carbon (BC), organic matter (OM), sulphate (SO4 2-), nitrate (NO3 -) and ammonium (NH4 +)-were estimated at geocoded residential addresses using bilinear interpolation. Multi-state models and accelerated failure time (AFT) models were applied to evaluate associations with dynamic CKM progression.
RESULTS: During 1.49 million person-years of follow-up, we documented 26 089 transitions from stage 0-1 to stage 2, 125 456 to stage 3, 18 561 to stage 4, and 39 614 deaths. Exposure to PM2.5 and all five constituents was significantly associated with CKM stage transitions, with effect estimates varying across stages. The transition from stage 3 to stage 4 showed the greatest risk, with a highest hazard ratio of 1.562 (95% CI: 1.548-1.577). AFT models further indicated that higher exposure levels were associated with accelerated CKM progression, with OM exhibiting the strongest effects across most transitions; for example, each standard deviation increase in OM exposure was associated with a 22.1% acceleration in transition time from stage 2 to stage 3.
CONCLUSION: Targeted mitigation of PM2.5 constituents, particularly organic matter, may help slow CKM progression and reduce the associated disease burden.