[Experimental renal insufficiency in rabbits produced by the intrarenal injection of cyanoacrylic ester].

Through a percutaneous intrarenal injection of 2 ml cyanoacrylic ester to each kidney, acute renal failure was induced in 10 experimental rabbits. Seven of the animals died as a consequence of uremia before a period of 64 hours. The other three remained alive for 96 hours although suffering from stable renal failure. Cyanoacrylic ester solidifies immediately after injection, leading to a hardened body which fills the renal pelvis, ureters and also the renal vessels. Each injection induces hydronephrosis and necrotic-hemorrhagic lesions, and infarcts in the case of vascular injection. With this simple technique immediate acute renal failure can be obtained experimentally without causing trauma or involving extrarenal structures.