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DOI 10.1038/s41591-024-03309-8

Медицинская библиотека · Nature medicine · 2024

Posthospitalization COVID-19 cognitive deficits at 1 year are global and associated with elevated brain injury markers and gray matter volume reduction.

Wood Greta K, Sargent Brendan F, Ahmad Zain-Ul-Abideen, Tharmaratnam Kukatharmini, Dunai Cordelia, Egbe Franklyn N, Martin Naomi H, Facer Bethany, Pendered Sophie L, Rogers Henry C, Hübel Christopher, van Wamelen Daniel J, Bethlehem Richard A I, Giunchiglia Valentina, Hellyer Peter J, Trender William, Kalsi Gursharan, Needham Edward, Easton Ava, Jackson Thomas A, Cunningham Colm, Upthegrove Rachel, Pollak Thomas A, Hotopf Matthew, Solomon Tom, Pett Sarah L, Shaw Pamela J, Wood Nicholas, Harrison Neil A, Miller Karla L, Jezzard Peter, Williams Guy, Duff Eugene P, Williams Steven, Zelaya Fernando, Smith Stephen M, Keller Simon, Broome Matthew, Kingston Nathalie, Husain Masud, Vincent Angela, Bradley John, Chinnery Patrick, Menon David K, Aggleton John P, Nicholson Timothy R, Taylor John-Paul, David Anthony S, Carson Alan, Bullmore Ed, Breen Gerome, Hampshire Adam, COVID-CNS Consortium, Michael Benedict D, Paddick Stella-Maria, Leek E Charles

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Аннотация

The spectrum, pathophysiology and recovery trajectory of persistent post-COVID-19 cognitive deficits are unknown, limiting our ability to develop prevention and treatment strategies. We report the 1-year cognitive, serum biomarker and neuroimaging findings from a prospective, national study of cognition in 351 COVID-19 patients who required hospitalization, compared with 2,927 normative matched controls. Cognitive deficits were global, associated with elevated brain injury markers and reduced anterior cingulate cortex volume 1 year after COVID-19. Severity of the initial infective insult, postacute psychiatric symptoms and a history of encephalopathy were associated with the greatest deficits. There was strong concordance between subjective and objective cognitive deficits. Longitudinal follow-up in 106 patients demonstrated a trend toward recovery. Together, these findings support the hypothesis that brain injury in moderate to severe COVID-19 may be immune-mediated, and should guide the development of therapeutic strategies.

Для цитирования: Wood Greta K, Sargent Brendan F, Ahmad Zain-Ul-Abideen, Tharmaratnam Kukatharmini, Dunai Cordelia, Egbe Franklyn N, Martin Naomi H, Facer Bethany, Pendered Sophie L, Rogers Henry C, Hübel Christopher, van Wamelen Daniel J, Bethlehem Richard A I, Giunchiglia Valentina, Hellyer Peter J, Trender William, Kalsi Gursharan, Needham Edward, Easton Ava, Jackson Thomas A, Cunningham Colm, Upthegrove Rachel, Pollak Thomas A, Hotopf Matthew, Solomon Tom, Pett Sarah L, Shaw Pamela J, Wood Nicholas, Harrison Neil A, Miller Karla L, Jezzard Peter, Williams Guy, Duff Eugene P, Williams Steven, Zelaya Fernando, Smith Stephen M, Keller Simon, Broome Matthew, Kingston Nathalie, Husain Masud, Vincent Angela, Bradley John, Chinnery Patrick, Menon David K, Aggleton John P, Nicholson Timothy R, Taylor John-Paul, David Anthony S, Carson Alan, Bullmore Ed, Breen Gerome, Hampshire Adam, COVID-CNS Consortium, Michael Benedict D, Paddick Stella-Maria, Leek E Charles. Posthospitalization COVID-19 cognitive deficits at 1 year are global and associated with elevated brain injury markers and gray matter volume reduction.. Nature medicine. 2024. DOI: 10.1038/s41591-024-03309-8.

Предметные рубрики MeSH

HumansCOVID-19MaleFemaleGray MatterMiddle AgedBiomarkersSARS-CoV-2Brain InjuriesCognitive DysfunctionAgedHospitalizationAdultProspective StudiesMagnetic Resonance ImagingNeuroimagingGyrus Cinguli
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