Behavioral effect of 1A-serotonin receptor agonist ipsapirone in mice previously defeated in male-male encounters.

The effect of 1A-serotonin receptor agonist ipsapirone (3 mg/kg) on mouse behavior was studied in the "wall" and Porsolt tests. The effects of the test drug were compared in intact animals and mice previously defeated in 20 intermale encounters (victims). Ipsapirone was ineffective in victims and effective in intact mice in the wall test. In the Porsolt test the drug prolonged stupor in victims.