Nature communications · 2024
A neuronal circuit driven by GLP-1 in the olfactory bulb regulates insulin secretion.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Montaner Mireia, Denom Jessica, Simon Vincent, Jiang Wanqing, Holt Marie K, Brierley Daniel I, Rouch Claude, Foppen Ewout, Kassis Nadim, Jarriault David, Khan Dawood, Eygret Louise, Mifsud Francois, Hodson David J, Broichhagen Johannes, Van Oudenhove Lukas, Fioramonti Xavier, Gault Victor, Cota Daniela, Reimann Frank, Gribble Fiona M, Migrenne-Li Stephanie, Trapp Stefan, Gurden Hirac, Magnan Christophe
Аннотация
Glucagon-like peptide 1 (GLP-1) stimulates insulin secretion and holds significant pharmacological potential. Nevertheless, the regulation of energy homeostasis by centrally-produced GLP-1 remains partially understood. Preproglucagon cells, known to release GLP-1, are found in the olfactory bulb (OB). We show that activating GLP-1 receptors (GLP-1R) in the OB stimulates insulin secretion in response to oral glucose in lean and diet-induced obese male mice. This is associated with reduced noradrenaline content in the pancreas and blocked by an α2-adrenergic receptor agonist, implicating functional involvement of the sympathetic nervous system (SNS). Inhibiting GABAA receptors in the paraventricular nucleus of the hypothalamus (PVN), the control centre of the SNS, abolishes the enhancing effect on insulin secretion induced by OB GLP-1R. Therefore, OB GLP-1-dependent regulation of insulin secretion relies on a relay within the PVN. This study provides evidence that OB GLP-1 signalling engages a top-down neural mechanism to control insulin secretion via the SNS.