Epilepsia · 2001
Stupor from lamotrigine toxicity.
Клинический случайСтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
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Sbei M, Campellone J V
Аннотация
PURPOSE: To report that acute lamotrigine poisoning may result in severe encephalopathy.
METHODS: A 55-year-old woman became stuporous after overdose with lamotrigine (LTG) and valproic acid (VPA) tablets. Evaluation revealed elevated serum LTG levels and no other etiology for encephalopathy.
RESULTS: LTG was withheld, and the patient experienced a complete recovery in conjunction with reduced serum levels.
CONCLUSIONS: LTG overdose may result in a severe but reversible encephalopathy, a previously undescribed phenomenon. LTG toxicity should be considered in patients taking this drug who have depressed mental status.
METHODS: A 55-year-old woman became stuporous after overdose with lamotrigine (LTG) and valproic acid (VPA) tablets. Evaluation revealed elevated serum LTG levels and no other etiology for encephalopathy.
RESULTS: LTG was withheld, and the patient experienced a complete recovery in conjunction with reduced serum levels.
CONCLUSIONS: LTG overdose may result in a severe but reversible encephalopathy, a previously undescribed phenomenon. LTG toxicity should be considered in patients taking this drug who have depressed mental status.