The relationship between elevated serum xenin and insulin resistance in women with polycystic ovary syndrome: a case-control study.

This study aims to determine whether serum xenin-25 levels are altered in women with polycystic ovary syndrome (PCOS). The study included 31 women diagnosed with PCOS according to the 2003 Rotterdam criteria and 30 healthy controls. The primary outcome was serum xenin-25 levels. Other variables evaluated were menstrual history, physical findings, Ferriman-Gallwey hirsutism score, blood pressure, transvaginal ultrasonography, fasting blood glucose, insulin, total cholesterol, LDL-cholesterol, HDL-cholesterol, triglycerides, C-reactive protein, follicle stimulating hormone, luteinizing hormone, estradiol, total testosterone, dehydroepiandrosterone sulfate, and day-21 progesterone. Median (min-max) values of xenin-25 were 45.50 pg/mL (7.10-656.40) and 9.85 pg/mL (7.00-564.40) for cases and controls, respectively, demonstrating a significant difference (Z = 2.803, p = .007). The ROC curve for xenin-25 predicting the PCOS risk had an area under the curve of 0.747. The optimal cutoff value of xenin-25 for detecting PCOS was calculated as ≥32.60 pg/mL with sensitivity, specificity values of 61.3% and 86.7%, respectively. A logistic regression model including xenin-25, FSH, Ferriman-Gallwey score, and Menstrual cycle frequency demonstrated the independent relationship of xenin-25 on PCOS (p < .05). This study demonstrated that xenin-25 may contribute to the diagnosis of PCOS. Further studies are needed to fully elucidate the effects of xenin-25 in the pathogenesis of PCOS.