Biological & pharmaceutical bulletin · 2009
Delta(9)-tetrahydrocannabinol enhances an increase of plasma corticosterone levels induced by forced swim-stress.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Sano Kazunori, Koushi Emi, Irie Keiichi, Higuchi Sei, Tsuchihashi Ryota, Kinjo Junei, Egashira Nobuaki, Oishi Ryozo, Uchida Naoki, Nagai Hiroshi, Nishimura Ryoji, Tanaka Hiroyuki, Morimoto Satoshi, Mishima Kenichi, Iwasaki Katsunori, Fujiwara Michihiro
Аннотация
The present study was designed to determine the effect of delta(9)-tetrahydrocannabinol (THC) on susceptibility to stress. We reported that THC significantly prolonged the immobility time during the forced swim-stress. The selective cannabinoid CB(1) receptor antagonist O-2050 significantly reduced the enhancement of immobility by THC. We investigated the effect of THC on levels of stress hormone corticosterone under non-stress and forced swim-stress conditions. THC did not affect plasma corticosterone levels under non-stress conditions. However, THC, together with forced swim-stress, significantly increased plasma corticosterone levels. This effect was inhibited by O-2050. This evidence suggests that THC, under stressful conditions, enhances the susceptibility of the hypothalamus-pituitary-adrenal-axis to stress via the CB(1) receptor, thereby increasing the risk of depression.