Strategies for the Prevention of Clostridioides difficile Infections.

Clostridioides difficile infection (CDI) continues to be a challenging issue for health care providers and place a heavy burden on health care facilities. The prevention of community-acquired and healthcare-acquired CDI rests on reducing the person-level risk factors (most commonly exposure to antibiotics and reducing the disruption of the normally protective intestinal microbiota). Prevention of facility-level CDI rests on multifaceted infection control practices that include antibiotic stewardship programs, prompt diagnosis and isolation of CDI cases, environmental disinfection and cleaning, and training of multidisciplinary teams. Use of probiotics of specific strains in high-risk patients is worthy of future investigation.