Periodontitis Is Associated With Serum Prostate Specific Antigen Concentrations in Chinese Male.

OBJECTIVE

This study aimed to clarify the association between periodontitis and prostate-specific antigen and to guide the early prostate-specific antigen screening of periodontitis patients.

MATERIALS AND

METHODS

1409 participants who visited West China Hospital of Sichuan University during 2021 and 2022 were included. Measurements were taken for blood pressure, fasting blood glucose, total cholesterol, triglycerides, C-reactive protein, carcinoembryonic antigen, and prostate-specific antigen. Participants went through periodontal examinations and were grouped into non-periodontitis individuals, mild periodontitis, moderate periodontitis, and severe periodontitis. Logistic regression was used to explore the potential associations.

RESULTS

Patients with severe periodontitis had significantly higher serum prostate-specific antigen compared to non-periodontitis individuals. No significant association between periodontitis and prostate-specific antigen was found in participants aged 20-40. In patients aged 41-80, regression models showed a significant association between elevated prostate-specific antigen and severe periodontitis, which was not significant in patients with mild and moderate periodontitis.

CONCLUSION

In Chinese men aged 20-80 years, serum prostate-specific antigen was significantly higher in patients with severe periodontitis than in non-periodontitis patients. Severe periodontitis was significantly associated with elevated PSA levels among elder patients.