BioMed research international · 2026
Antibacterial Activity of Corryocactus brevistylus (Sanky) Methanolic Extract Against Staphylococcus aureus and Enterococcus faecalis.
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Aquino-Ortega Ronald, Carrillo-Ng Hugo, Paucar-Menacho Luz María, Aguilar-Luis Miguel Angel, Silva-Caso Wilmer, Salvatierra-Pajuelo Yulissa Milagros, Repo-Carrasco-Valencia Ritva, Del Valle-Mendoza Juana
Аннотация
BACKGROUND: Staphylococcus aureus and Enterococcus faecalis are bacteria for which new antibiotics are urgently needed. Corryocactus brevistylus is a Peruvian cactus with an antibacterial effect that has not yet been studied.
OBJECTIVE: To determine the antibacterial effect of C. brevistylus methanol extract against S. aureus (ATCC 6538) and E. faecalis (ATCC 29212).
METHODS: Sanky fruits were extracted with methanol (1:2, w/v). Agar well diffusion tests were used by preparing wells with the experimental solutions cultivated in aerobic conditions for 24 h at 37°C. Six independent tests were prepared for each type of bacteria, using penicillin-streptomycin and chlorhexidine as positive controls. The MIC was determined using the microdilution method as described by the CLSI.
RESULTS: The antibacterial effect of the methanol extract was dose-dependent, with inhibition zones of 23.33 ± 0.72 and 24.34 ± 0.55 mm against S. aureus and E. faecalis, respectively, at the highest concentration. Meanwhile, penicillin-streptomycin (10 U) and chlorhexidine produced inhibition zones comparable to the extract at the highest concentration. The MIC achieved by the extract was 15.6 mg/mL for both S. aureus and E. faecalis, while the MBC for S. aureus was 62.5 mg/mL and for E. faecalis 31.3 mg/mL.
CONCLUSIONS: Weak antibacterial potency was observed in the methanolic extract of C. brevistylus against the strains of S. aureus and E. faecalis.
OBJECTIVE: To determine the antibacterial effect of C. brevistylus methanol extract against S. aureus (ATCC 6538) and E. faecalis (ATCC 29212).
METHODS: Sanky fruits were extracted with methanol (1:2, w/v). Agar well diffusion tests were used by preparing wells with the experimental solutions cultivated in aerobic conditions for 24 h at 37°C. Six independent tests were prepared for each type of bacteria, using penicillin-streptomycin and chlorhexidine as positive controls. The MIC was determined using the microdilution method as described by the CLSI.
RESULTS: The antibacterial effect of the methanol extract was dose-dependent, with inhibition zones of 23.33 ± 0.72 and 24.34 ± 0.55 mm against S. aureus and E. faecalis, respectively, at the highest concentration. Meanwhile, penicillin-streptomycin (10 U) and chlorhexidine produced inhibition zones comparable to the extract at the highest concentration. The MIC achieved by the extract was 15.6 mg/mL for both S. aureus and E. faecalis, while the MBC for S. aureus was 62.5 mg/mL and for E. faecalis 31.3 mg/mL.
CONCLUSIONS: Weak antibacterial potency was observed in the methanolic extract of C. brevistylus against the strains of S. aureus and E. faecalis.