Brain & spine · 2026
Technical and anatomical determinants of ischemic complications in unruptured middle cerebral artery aneurysm surgery: The role of temporary arterial occlusion.
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Ribeiro Lucas, Szabo Vivien, Hernandez Jennifer, Le Corre Marine
Аннотация
INTRODUCTION: Ischemic complications (IC) remain a major source of morbidity following microsurgical treatment of unruptured middle cerebral artery (MCA) aneurysms. The contribution of temporary arterial occlusion (TAO) to ischemic risk remains debated, particularly given potential confounding by anatomical and intraoperative factors.
RESEARCH QUESTION: What are the primary determinants of clinically evident IC in unruptured MCA aneurysm surgery, and what is the role of TAO?
METHODS: We retrospectively analyzed consecutive patients undergoing clipping of unruptured MCA aneurysms between 2023 and 2025. Clinically evident IC was defined as a new postoperative neurological deficit with corresponding ischemic lesions on MRI in symptomatic patients only. Associations with IC were assessed using Firth's penalized logistic regression.
RESULTS: Forty-seven patients were included. TAO was used in 60% of cases and was associated with larger aneurysm size (8.3 ± 2.7 vs 6.8 ± 2.4 mm; p = 0.048). TAO, including repeated and prolonged applications, was not associated with IC (OR 0.67, 95% CI 0.06-6.97; p = 0.74). A short pre-aneurysmal M1 segment (OR 30.4; p = 0.034) and intraoperative rupture (OR 17.4; p = 0.031) were associated with IC. All IC occurred in patients with a short M1 segment and were related to perforator injury during dissection or clipping. Complete occlusion was achieved in all cases; morbidity was 4.3%.
CONCLUSION: Clinically evident ischemic complications are primarily driven by anatomical constraints and clipping strategy rather than TAO. TAO should be considered a technical adjunct rather than a dominant determinant of ischemic risk. These findings warrant validation in larger prospective studies.
RESEARCH QUESTION: What are the primary determinants of clinically evident IC in unruptured MCA aneurysm surgery, and what is the role of TAO?
METHODS: We retrospectively analyzed consecutive patients undergoing clipping of unruptured MCA aneurysms between 2023 and 2025. Clinically evident IC was defined as a new postoperative neurological deficit with corresponding ischemic lesions on MRI in symptomatic patients only. Associations with IC were assessed using Firth's penalized logistic regression.
RESULTS: Forty-seven patients were included. TAO was used in 60% of cases and was associated with larger aneurysm size (8.3 ± 2.7 vs 6.8 ± 2.4 mm; p = 0.048). TAO, including repeated and prolonged applications, was not associated with IC (OR 0.67, 95% CI 0.06-6.97; p = 0.74). A short pre-aneurysmal M1 segment (OR 30.4; p = 0.034) and intraoperative rupture (OR 17.4; p = 0.031) were associated with IC. All IC occurred in patients with a short M1 segment and were related to perforator injury during dissection or clipping. Complete occlusion was achieved in all cases; morbidity was 4.3%.
CONCLUSION: Clinically evident ischemic complications are primarily driven by anatomical constraints and clipping strategy rather than TAO. TAO should be considered a technical adjunct rather than a dominant determinant of ischemic risk. These findings warrant validation in larger prospective studies.