People with HIV receiving suppressive antiretroviral therapy show typical antibody durability after dual COVID-19 vaccination, and strong third dose responses.
Обработка статьи · этапы, ошибки и управление
Ошибки и ограничения
История · было → стало
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Lapointe Hope R, Mwimanzi Francis, Cheung Peter K, Sang Yurou, Yaseen Fatima, Umviligihozo Gisele, Kalikawe Rebecca, Speckmaier Sarah, Moran-Garcia Nadia, Datwani Sneha, Duncan Maggie C, Agafitei Olga, Ennis Siobhan, Young Landon, Ali Hesham, Ganase Bruce, Omondi F Harrison, Dong Winnie, Toy Junine, Sereda Paul, Burns Laura, Costiniuk Cecilia T, Cooper Curtis, Anis Aslam H, Leung Victor, Holmes Daniel, DeMarco Mari L, Simons Janet, Hedgcock Malcolm, Prystajecky Natalie, Lowe Christopher F, Pantophlet Ralph, Romney Marc G, Barrios Rolando, Guillemi Silvia, Brumme Chanson J, Montaner Julio S G, Hull Mark, Harris Marianne, Niikura Masahiro, Brockman Mark A, Brumme Zabrina L
Аннотация
METHODS: We measured antibodies against the SARS-CoV-2 spike protein receptor-binding domain, ACE2 displacement and viral neutralization against wild-type and Omicron strains up to six months following two-dose vaccination, and one month following the third dose, in 99 PLWH receiving suppressive antiretroviral therapy, and 152 controls.
RESULTS: Though humoral responses naturally decline following two-dose vaccination, we found no evidence of lower antibody concentrations nor faster rates of antibody decline in PLWH compared to controls after accounting for sociodemographic, health and vaccine-related factors. We also found no evidence of poorer viral neutralization in PLWH after two doses, nor evidence that a low nadir CD4+ T-cell count compromised responses. Post-third-dose humoral responses substantially exceeded post-second-dose levels, though anti-Omicron responses were consistently weaker than against wild-type.Nevertheless, post-third-dose responses in PLWH were comparable to or higher than controls. An mRNA-1273 third dose was the strongest consistent correlate of higher post-third-dose responses.
CONCLUSION: PLWH receiving suppressive antiretroviral therapy mount strong antibody responses after two- and three-dose COVID-19 vaccination. Results underscore the immune benefits of third doses in light of Omicron.